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The antibody against TRIM40 was raised in rabbit using the Synthetic peptide of Human TRIM40 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against TRIM40 was raised in rabbit using the Synthetic peptide of Human TRIM40 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-26023A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRIM40 |
| Target Synonyms | TRIM40 antibody; RNF35 antibody; Tripartite motif-containing protein 40 antibody; Probable E3 NEDD8-protein ligase antibody; RING finger protein 35 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human TRIM40 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q6P9F5 |
Uniprot Id
Q6P9F5
Target Species
Human
Target Name
TRIM40
Target Full Name
E3 ubiquitin ligase TRIM40
Target Function
E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating DDX58 and IFIH1 receptors, leading to their proteasomal degradation. Promotes also the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation.
Target Protein Families
TRIM/RBCC family
Target Tissue Specificity
Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.
Target Synonyms
TRIM40; RNF35; Tripartite motif-containing protein 40; Probable E3 NEDD8-protein ligase; RING finger protein 35
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