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The antibody against NLRP7 was raised in rabbit using the Synthetic peptide of Human NLRP7 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against NLRP7 was raised in rabbit using the Synthetic peptide of Human NLRP7 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$299.00
| Cat.No | ADC-27075A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NLRP7 |
| Target Synonyms | CLR19.4 antibody; FLJ94610 antibody; HYDM antibody; MGC126470 antibody; MGC126471 antibody; NACHT, leucine rich repeat and PYD containing 7 antibody; NACHT, leucine rich repeat and pyrin domain containing 7 antibody; PAN7 antibody; PYPAF3 antibody; PYRIN-containing APAF1-like protein 3 antibody, LRR and PYD containing protein 7 antibody; NACHT, LRR and PYD domains containing protein 7 antibody; NACHT, LRR and PYD domains-containing protein 7 antibody; NALP7 antibody; NALP7_HUMAN antibody; NLR family, pyrin domain containing 7 antibody; NLRP7 antibody; NOD12 antibody; Nucleotide-binding oligomerization domain protein 12 antibody; Nucleotide-binding oligomerization domain | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human NLRP7 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WX94 |
Uniprot Id
Q8WX94
Target Species
Human
Target Name
NLRP7
Target Full Name
NACHT, LRR and PYD domains-containing protein 7
Target Function
Inhibits CASP1/caspase-1-dependent IL1B secretion.
Target Involvement
Hydatidiform mole, recurrent, 1 (HYDM1)
Target Protein Families
NLRP family
Target Tissue Specificity
Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle.
Target Synonyms
CLR19.4; FLJ94610; HYDM; MGC126470; MGC126471; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains containing protein 7; NACHT, LRR and PYD domains-containing protein 7; NALP7; NALP7_HUMAN; NLR family, pyrin domain containing 7; NLRP7; NOD12; Nucleotide-binding oligomerization domain protein 12; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; PYRIN-containing APAF1-like protein 3
Target Background
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
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