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The antibody against SCAF8 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human RBM16. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against SCAF8 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human RBM16. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of JK cells using RBM16 Polyclonal Antibody
| Cat.No | ADC-35882A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SCAF8 |
| Target Synonyms | SCAF8 antibody; CCAP7 antibody; KIAA1116 antibody; RBM16 antibody; SR-related and CTD-associated factor 8 antibody; CDC5L complex-associated protein 7 antibody; RNA-binding motif protein 16 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human RBM16. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPN6 |
Uniprot Id
Q9UPN6
Target Species
Human
Target Name
SCAF8
Target Full Name
SR-related and CTD-associated factor 8
Target Function
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.
Target Subcellular Location
Nucleus. Nucleus matrix.
Target Synonyms
SCAF8; CCAP7; KIAA1116; RBM16; SR-related and CTD-associated factor 8; CDC5L complex-associated protein 7; RNA-binding motif protein 16
Target Background
Enables RNA binding activity and RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled and positive regulation of DNA-templated transcription, elongation. Located in nucleoplasm.
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