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The antibody against MYB was raised in rabbit using the Peptide sequence around phosphorylation site of serine 532 (V-E-S(p)-P-T) derived from Human Myb. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, IHC.
The antibody against MYB was raised in rabbit using the Peptide sequence around phosphorylation site of serine 532 (V-E-S(p)-P-T) derived from Human Myb. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, IHC.
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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Myb (Phospho-Ser532) antibody. The picture on the right is treated with the synthesized peptide.
| Cat.No | ADC-40571A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MYB |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence around phosphorylation site of serine 532 (V-E-S(p)-P-T) derived from Human Myb. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P10242 |
Uniprot Id
P10242
Target Species
Human
Target Name
MYB
Target Full Name
Transcriptional activator Myb
Target Function
Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Target Subcellular Location
Nucleus.
Target Synonyms
C myb; c myb protein (140 AA); c-myb protein (140 AA); c-myb_CDS; c-myb10A_CDS; c-myb13A_CDS; c-myb14A_CDS; c-myb8B_CDS; Cmyb; efg; Myb; MYB proto-oncogene transcription factor; MYB_HUMAN; ONCOGENE AMV; Oncogene MYB; Proto oncogene c Myb; Proto-oncogene c-Myb; Transcriptional activator Myb; v myb avian myeloblastosis viral oncogene homolog; v-myb avian myeloblastosis viral oncogene homolog
Target Background
This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants.
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