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Rabbit anti-Human OAT Polyclonal Antibody

The antibody against OAT was raised in rabbit using the Synthesized peptide derived from Internal of Human OAT. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.

ADC-40714A

The antibody against OAT was raised in rabbit using the Synthesized peptide derived from Internal of Human OAT. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.

$297.00

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Specifications


Cat.No ADC-40714A ClonalityPolyclonal
Host SpeciesRabbitTarget NameOAT
FormLiquidSpecies ReactivityHuman, Mouse, Rat
Storage BufferPH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+)Purification MethodThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationELISA, WBStorageUpon receipt

Immunogen Information


Immunogen DescriptionSynthesized peptide derived from Internal of Human OAT.Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP04181
Background Information
  • Uniprot Id

    P04181

  • Target Species

    Human

  • Target Name

    OAT

  • Target Full Name

    Ornithine aminotransferase, mitochondrial

  • Target Function

    Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate.

  • Target Involvement

    Hyperornithinemia with gyrate atrophy of choroid and retina (HOGA)

  • Target Subcellular Location

    Mitochondrion matrix.

  • Target Protein Families

    Class-III pyridoxal-phosphate-dependent aminotransferase family

  • Target Synonyms

    OAT; Ornithine aminotransferase; mitochondrial; EC 2.6.1.13; Ornithine delta-aminotransferase; Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase; hepatic form; Ornithine aminotransferase; renal form]

  • Target Background

    This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.

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