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The antibody against AIM2 was raised in rabbit using the Synthesized peptide derived from internal of Human AIM2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against AIM2 was raised in rabbit using the Synthesized peptide derived from internal of Human AIM2. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extracts from HUVEC cells, using AIM2 antibody.
| Cat.No | ADC-41714A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | AIM2 |
| Target Synonyms | Absent in melanoma 2 antibody; AIM 2 antibody; Aim2 antibody; AIM2_HUMAN antibody; Interferon-inducible protein AIM2 antibody; OTTHUMP00000035296 antibody; PYHIN4 antibody | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human AIM2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14862 |
Uniprot Id
O14862
Target Species
Human
Target Name
AIM2
Target Full Name
Interferon-inducible protein AIM2
Target Function
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Target Subcellular Location
Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.
Target Protein Families
HIN-200 family
Target Tissue Specificity
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Target Synonyms
Absent in melanoma 2; AIM 2; Aim2; AIM2_HUMAN; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4
Target Background
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
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