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The antibody against SCAF8 was raised in rabbit using the Human RBM16 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against SCAF8 was raised in rabbit using the Human RBM16 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC, IF.
$600.00
| Cat.No | ADC-52099A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SCAF8 |
| Target Synonyms | SCAF8 antibody; CCAP7 antibody; KIAA1116 antibody; RBM16 antibody; SR-related and CTD-associated factor 8 antibody; CDC5L complex-associated protein 7 antibody; RNA-binding motif protein 16 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Human RBM16 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UPN6 |
Uniprot Id
Q9UPN6
Target Species
Human
Target Name
SCAF8
Target Full Name
SR-related and CTD-associated factor 8
Target Function
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation.
Target Subcellular Location
Nucleus. Nucleus matrix.
Target Synonyms
SCAF8; CCAP7; KIAA1116; RBM16; SR-related and CTD-associated factor 8; CDC5L complex-associated protein 7; RNA-binding motif protein 16
Target Background
Enables RNA binding activity and RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled and positive regulation of DNA-templated transcription, elongation. Located in nucleoplasm.
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