Rabbit anti-Human CBR4 Polyclonal Antibody

Uniprot Id

Q8N4T8

Target Species

Human

Target Name

CBR4

Target Full Name

3-oxoacyl-[acyl-carrier-protein] reductase

Target Function

Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).

Target Subcellular Location

Mitochondrion matrix.

Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family

Target Tissue Specificity

Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues.

Target Research Area

Signal Transduction

Target Synonyms

3 oxoacyl [acyl carrier protein] reductase; 3-oxoacyl-[acyl-carrier-protein] reductase; Carbonic reductase 4; Carbonyl reductase 4; Carbonyl reductase family member 4; CBR 4; Cbr4; CBR4_HUMAN; FLJ14431; Quinone reductase CBR4; SDR45C1; Short chain dehydrogenase/reductase family 45C member 1

Target Background

Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex.