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The antibody against ASMT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
The antibody against ASMT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on IHC-P, ELISA.
Immunohistochemistry analysis of paraffin-embedded rat heart using ASMT antibody at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
| Cat.No | ADA-00333A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ASMT |
| Target Synonyms | ASMTY; HIOMT; HIOMTY; ASMT | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human ASMT (NP_001164510.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P46597 | Immunogen Sequence |
Uniprot Id
P46597
Target Species
Human
Target Name
ASMT
Target Full Name
Acetylserotonin O-methyltransferase
Target Function
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, Cation-independent O-methyltransferase family
Target Tissue Specificity
Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level, and not at the protein level.
Target Research Area
Cell Biology
Target Synonyms
acetylserotonin methyltransferase (Y chromosome); acetylserotonin N-methyltransferase; Acetylserotonin O-methyltransferase; ASMT; ASMTY; HIOM_HUMAN; HIOMT; HIOMTY; Hydroxyindole O-methyltransferase; OTTHUMP00000022834; OTTHUMP00000022835; OTTHUMP00000022836
Target Background
This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene.
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