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The antibody against DGKQ was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 683-942 of human DGKQ (NP_001338.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DGKQ was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 683-942 of human DGKQ (NP_001338.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04056A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DGKQ |
| Target Synonyms | DAGK; DAGK4; DAGK7; DGKQ | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, K-562, MCF-7, Mouse brain | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 683-942 of human DGKQ (NP_001338.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P52824 | Immunogen Sequence |
Uniprot Id
P52824
Target Species
Human
Target Name
DGKQ
Target Full Name
Diacylglycerol kinase theta
Target Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytosol. Cell membrane. Cell junction, synapse. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Nucleus matrix.
Target Protein Families
Eukaryotic diacylglycerol kinase family
Target Synonyms
DAG kinase theta; DAGK4; DAGK7; DGK theta; DGK-theta; Dgkq; DGKQ_HUMAN; Diacylglycerol kinase delta (110kD); Diacylglycerol kinase theta 110kDa; Diacylglycerol kinase theta; Diglyceride kinase theta
Target Background
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.
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