Rabbit anti-Human NDP Polyclonal Antibody

Uniprot Id

Q00604

Target Species

Human

Target Name

NDP

Target Full Name

Norrin

Target Function

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Target Involvement

Norrie disease (ND); Vitreoretinopathy, exudative 2 (EVR2)

Target Subcellular Location

Secreted.

Target Tissue Specificity

Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain.

Target Research Area

Neuroscience

Target Synonyms

(Norrie disease protein)(X-linked exudative vitreoretinopathy 2 protein)

Target Background

This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy.