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The antibody against SEMA3A was raised in rabbit using the Recombinant Human Semaphorin-3A protein (357-445AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against SEMA3A was raised in rabbit using the Recombinant Human Semaphorin-3A protein (357-445AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-07677A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SEMA3A |
| Target Synonyms | SEMA3A antibody; SEMAD antibody; Semaphorin-3A antibody; Semaphorin III antibody; Sema III antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Semaphorin-3A protein (357-445AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14563 |
Uniprot Id
Q14563
Target Species
Human
Target Name
SEMA3A
Target Full Name
Semaphorin-3A
Target Function
Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.
Target Involvement
Hypogonadotropic hypogonadism 16 with or without anosmia (HH16)
Target Subcellular Location
Secreted.
Target Protein Families
Semaphorin family
Target Tissue Specificity
Expressed in the dorsal root ganglia.
Target Synonyms
SEMA3A; SEMAD; Semaphorin-3A; Semaphorin III; Sema III
Target Background
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
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