Rabbit anti-Human ASPA Polyclonal Antibody

Uniprot Id

P45381

Target Species

Human

Target Name

ASPA

Target Full Name

Aspartoacylase

Target Function

Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.

Target Involvement

Canavan disease (CAND)

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

AspA/AstE family, Aspartoacylase subfamily

Target Tissue Specificity

Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.

Target Research Area

Signal Transduction

Target Synonyms

ACY 2; ACY-2; ACY2; ACY2_HUMAN; Aminoacylase 2; Aminoacylase-2; Aminoacylase2; ASP; ASPA; Aspartoacylase (aminoacylase 2; Canavan disease); Aspartoacylase (Canavan disease); Aspartoacylase; NUR 7; NUR7; OTTMUSP00000006437; RP23-213I10.1; Small lethargic

Target Background

This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.