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The antibody against BCAN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against BCAN was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00997A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BCAN |
| Target Synonyms | BEHAB; CSPG7; BCAN | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, K-562, MCF7, Mouse brain, Raji | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 762-911 of human BCAN (NP_068767.3). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | VPLLYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPELPLAQVFGRPRLRYEVDTVLRYRCREGLAQRNLPLIRCQENGRWEAPQISCVPRRPARALHPEEDPEGRQGRLLGRWKALLIPPSSPMPGP | Uniprot ID | Q96GW7 |
Uniprot Id
Q96GW7
Target Species
Human
Target Name
BCAN
Target Full Name
Brevican core protein
Target Function
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Target Subcellular Location
[Isoform 1]: Secreted, extracellular space, extracellular matrix.; [Isoform 2]: Membrane; Lipid-anchor, GPI-anchor.
Target Protein Families
Aggrecan/versican proteoglycan family
Target Tissue Specificity
Expressed in the retina, specifically in the inner nuclear layer, inner plexiform layer and ganglion cell layer (at protein level).
Target Synonyms
BCAN; BEHAB; CSPG7; UNQ2525/PRO6018; Brevican core protein; Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
Target Background
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants.
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