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The antibody against C1QA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_001334394.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against C1QA was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_001334394.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
Western blot analysis of RPMI 8226, using C1QA Rabbit pAb at 1:2000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
| Cat.No | ADA-11887A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | C1QA |
| Target Synonyms | C1QD1; C1QA | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | RPMI 8226 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_001334394.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P02745 | Immunogen Sequence |
Uniprot Id
P02745
Target Species
Human
Target Name
C1QA
Target Full Name
Complement C1q subcomponent subunit A
Target Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Target Involvement
Complement component C1q deficiency (C1QD)
Target Subcellular Location
Secreted.
Target Research Area
Immunology
Target Synonyms
C1qa; C1QA_HUMAN; Complement C1q subcomponent subunit A; Complement component 1 q subcomponent A chain; Complement component 1 q subcomponent alpha polypeptide; Complement component C1q A chain
Target Background
This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants.
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