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The antibody against CACNG2 was raised in rabbit using the Synthetic Peptide as the immunogen. This antibody exists as a non-conjugated isotype IgG. This antibody has been validated on WB, IHC.
The antibody against CACNG2 was raised in rabbit using the Synthetic Peptide as the immunogen. This antibody exists as a non-conjugated isotype IgG. This antibody has been validated on WB, IHC.
$167.00
Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using CACNG2 Polyclonal Antibody.
Western blot analysis of 1) Human Brain Tissue, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using CACNG2 Polyclonal Antibody.2
| Cat.No | ADC-33123A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CACNG2 |
| Target Synonyms | CACNG2; Voltage-dependent calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | PH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol., PBS | Conjugate | Non-conjugated |
| Application | IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthetic Peptide | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y698 |
Uniprot Id
Q9Y698
Target Species
Human
Target Name
CACNG2
Target Full Name
Voltage-dependent calcium channel gamma-2 subunit
Target Function
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.
Target Involvement
Mental retardation, autosomal dominant 10 (MRD10)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.
Target Protein Families
PMP-22/EMP/MP20 family, CACNG subfamily
Target Tissue Specificity
Brain.
Target Synonyms
CACNG2; Voltage-dependent calcium channel gamma-2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2
Target Background
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability.
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