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The antibody against CD28 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CD28. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
The antibody against CD28 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human CD28. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, ELISA.
$167.00
Western Blot analysis of K562 cells using CD28 Polyclonal Antibody
| Cat.No | ADC-37106A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD28 |
| Target Synonyms | CD28; T-cell-specific surface glycoprotein CD28; TP44; CD antigen CD28 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human CD28. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P10747 |
Uniprot Id
P10747
Target Species
Human
Target Name
CD28
Target Full Name
T-cell-specific surface glycoprotein CD28
Target Function
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.
Target Tissue Specificity
Expressed in T-cells and plasma cells, but not in less mature B-cells.
Target Synonyms
CD28; T-cell-specific surface glycoprotein CD28; TP44; CD antigen CD28
Target Background
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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