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The antibody against CLDN7 was raised in rabbit using the Peptide sequence around phosphorylation site of tyrosine 210 (S-K-E-Y(p)-V) derived from Human Claudin 7. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB.
The antibody against CLDN7 was raised in rabbit using the Peptide sequence around phosphorylation site of tyrosine 210 (S-K-E-Y(p)-V) derived from Human Claudin 7. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB.
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Western blot analysis of extracts from 3T3 cells (Lane 2), using Claudin 7 (Phospho-Tyr210) Antibody. The lane on the left is treated with antigen-specific peptide.
| Cat.No | ADC-42692A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CLDN7 |
| Target Synonyms | CLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Peptide sequence around phosphorylation site of tyrosine 210 (S-K-E-Y(p)-V) derived from Human Claudin 7. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O95471 |
Uniprot Id
O95471
Target Species
Human
Target Name
CLDN7
Target Full Name
Claudin-7
Target Function
Plays a major role in tight junction-specific obliteration of the intercellular space.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Cell junction, tight junction.
Target Protein Families
Claudin family
Target Tissue Specificity
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (L
Target Synonyms
CLDN7; CEPTRL2; CPETRL2; Claudin-7; CLDN-7
Target Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
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