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The antibody against CNTF was raised in rabbit using the Recombinant Human Ciliary neurotrophic factor protein (4-196AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against CNTF was raised in rabbit using the Recombinant Human Ciliary neurotrophic factor protein (4-196AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-51049A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CNTF |
| Target Synonyms | Ciliary neurotrophic factor antibody; CNTF antibody; CNTF_HUMAN antibody; HCNTF antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ciliary neurotrophic factor protein (4-196AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P26441 |
Uniprot Id
P26441
Target Species
Human
Target Name
CNTF
Target Full Name
Ciliary neurotrophic factor
Target Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Target Subcellular Location
Cytoplasm.
Target Protein Families
CNTF family
Target Tissue Specificity
Nervous system.
Target Research Area
Neuroscience, Developmental Biology
Target Synonyms
Ciliary neurotrophic factor; CNTF; CNTF_HUMAN; HCNTF
Target Background
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
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