Rabbit anti-Human CPSF6 Polyclonal Antibody

Uniprot Id

Q16630

Target Species

Human

Target Name

CPSF6

Target Full Name

Cleavage and polyadenylation specificity factor subunit 6

Target Function

Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export.; (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro).

Target Subcellular Location

Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm.

Target Protein Families

RRM CPSF6/7 family

Target Synonyms

CFIM; CFIm68; cleavage and polyadenylation specific factor 6; 68kDa; Cleavage and polyadenylation specificity factor 68 kDa subunit; Cleavage and polyadenylation specificity factor subunit 6; cleavage factor Im complex 68 kDa subunit; CPSF 68 kDa subunit; Cpsf6; CPSF6_HUMAN; HPBRII 4; HPBRII 7; Pre mRNA cleavage factor Im 68 kDa subunit; pre-mRNA cleavage factor I; 68kD subunit; pre-mRNA cleavage factor Im (68kD); Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPBRII 4/7; Protein HPBRII-4/7

Target Background

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.