Rabbit anti-Human DACH1 Polyclonal Antibody

Uniprot Id

Q9UI36

Target Species

Human

Target Name

DACH1

Target Full Name

Dachshund homolog 1

Target Function

Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain.

Target Subcellular Location

Nucleus.

Target Protein Families

DACH/dachshund family

Target Tissue Specificity

Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.

Target Synonyms

DACH; Dach1; DACH1_HUMAN; Dachshund family transcription factor 1; dachshund homolog 1 (Drosophila); Dachshund homolog 1; Dachsund homolog 1; FLJ10138; OTTHUMP00000018494

Target Background

This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.