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The antibody against DIMT1 was raised in rabbit using the Recombinant Human Probable dimethyladenosine transferase protein (1-313AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against DIMT1 was raised in rabbit using the Recombinant Human Probable dimethyladenosine transferase protein (1-313AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue using DIMT1 Antibody at dilution of 1:1002
| Cat.No | ADC-45006A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DIMT1 |
| Target Synonyms | N' adenosyl(rRNA) dimethyltransferase antibody; S adenosylmethionine 6 N', N' adenosyl(rRNA) dimethyltransferase antibody; S-adenosylmethionine-6-N'' antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Probable dimethyladenosine transferase protein (1-313AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UNQ2 |
Uniprot Id
Q9UNQ2
Target Species
Human
Target Name
DIMT1
Target Full Name
Dimethyladenosine transferase
Target Function
Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity.
Target Subcellular Location
Nucleus, nucleoplasm. Nucleus, nucleolus.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, rRNA adenine N(6)-methyltransferase family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; 18S rRNA dimethylase; DIM1; DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); DIM1 dimethyladenosine transferase 1 homolog; DIM1 dimethyladenosine transferase 1 like ; DIM1 dimethyladenosine transferase 1-like; Dimethyladenosine transferase; DIMT1; DIMT1_HUMAN; DIMT1L; HSA9761; HUSSY5; N''-adenosyl(rRNA) dimethyltransferase; Probable 18S rRNA (adenine(1779) N(6)/adenine(1780) N(6)) dimethyltransferase; Probable 18S rRNA dimethylase; Probable dimethyladenosine transferase; Probable S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase; S adenosylmethionine 6 N',N' adenosyl(rRNA) dimethyltransferase; S-adenosylmethionine-6-N''
Target Background
The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus.
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