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The antibody against DOCK1 was raised in rabbit using the Human DOCK1-Specific as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IF.
The antibody against DOCK1 was raised in rabbit using the Human DOCK1-Specific as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IF.
$600.00
| Cat.No | ADC-51248A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DOCK1 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.02% sodium azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Human DOCK1-Specific | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q14185 |
Uniprot Id
Q14185
Target Species
Human
Target Name
DOCK1
Target Full Name
Dedicator of cytokinesis protein 1
Target Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
Target Subcellular Location
Cytoplasm. Membrane.
Target Protein Families
DOCK family
Target Tissue Specificity
Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
Target Synonyms
180 kDa protein downstream of CRK; Ced5; Dedicator of Cytokinesis 1; Dedicator of cytokinesis protein 1; DOCK 1; DOCK 180; DOCK1; DOCK1_HUMAN; DOCK180
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