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The antibody against DOCK10 was raised in rabbit using the Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against DOCK10 was raised in rabbit using the Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-22742A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DOCK10 |
| Target Synonyms | DOCK10 antibody; KIAA0694 antibody; ZIZ3Dedicator of cytokinesis protein 10 antibody; Zizimin-3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q96BY6 |
Uniprot Id
Q96BY6
Target Species
Human
Target Name
DOCK10
Target Full Name
Dedicator of cytokinesis protein 10
Target Function
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
Target Subcellular Location
Nucleus. Cytoplasm. Cell projection, dendritic spine.
Target Protein Families
DOCK family
Target Tissue Specificity
Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
Target Synonyms
DOCK10; KIAA0694; ZIZ3Dedicator of cytokinesis protein 10; Zizimin-3
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