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The antibody against DPYD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_000101.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against DPYD was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_000101.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-04570A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DPYD |
| Target Synonyms | DHP; DPD; DYPD; DHPDHASE; DPYD | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse liver, THP-1 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_000101.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATETLILAFSLMNHL | Uniprot ID | Q12882 |
Uniprot Id
Q12882
Target Species
Human
Target Name
DPYD
Target Full Name
Dihydropyrimidine dehydrogenase [NADP(+)]
Target Function
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Target Involvement
Dihydropyrimidine dehydrogenase deficiency (DPYDD)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Dihydropyrimidine dehydrogenase family
Target Tissue Specificity
Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
Target Synonyms
DHP; DHPDHase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydropyrimidine dehydrogenase [NADP+]; Dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; DPYD; DPYD_HUMAN; MGC132008; MGC70799; OTTHUMP00000058954
Target Background
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene.
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