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The antibody against DYNC1I1 was raised in rabbit using the Recombinant Human Cytoplasmic dynein 1 intermediate chain 1 protein (1-220AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against DYNC1I1 was raised in rabbit using the Recombinant Human Cytoplasmic dynein 1 intermediate chain 1 protein (1-220AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using DYNC1I1 Antibody at dilution of 1:1002
| Cat.No | ADC-16719A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DYNC1I1 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cytoplasmic dynein 1 intermediate chain 1 protein (1-220AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14576 |
Uniprot Id
O14576
Target Species
Human
Target Name
DYNC1I1
Target Full Name
Cytoplasmic dynein 1 intermediate chain 1
Target Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
Target Subcellular Location
Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
Target Protein Families
Dynein intermediate chain family
Target Research Area
Signal Transduction
Target Synonyms
Cytoplasmic dynein 1 intermediate chain 1; Cytoplasmic dynein intermediate chain 1; cytosolic; DC1I1_HUMAN; DH IC 1; DH IC-1; DH IC1; DNCI1; DNCIC1; Dync1i1; Dynein cytoplasmic 1 intermediate chain 1; Dynein intermediate chain 1; Dynein intermediate chain 1; cytosolic; Dynein; cytoplasmic; intermediate polypeptide 1
Target Background
Enables spectrin binding activity. Involved in vesicle transport along microtubule. Located in several cellular components, including kinetochore; recycling endosome; and spindle pole.
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