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The antibody against EDEM2 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human EDEM2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against EDEM2 was raised in rabbit using the Synthesized peptide derived from the C-terminal region of Human EDEM2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
| Cat.No | ADC-34542A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | EDEM2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the C-terminal region of Human EDEM2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BV94 |
Uniprot Id
Q9BV94
Target Species
Human
Target Name
EDEM2
Target Full Name
ER degradation-enhancing alpha-mannosidase-like protein 2
Target Function
Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins.
Target Subcellular Location
Endoplasmic reticulum lumen.
Target Protein Families
Glycosyl hydrolase 47 family
Target Tissue Specificity
Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.
Target Synonyms
bA4204.1; C20orf31; C20orf49; EDEM 2; EDEM2; EDEM2_HUMAN; ER degradation enhancer mannosidase alpha like 2; ER degradation enhancing alpha mannosidase like 2; ER degradation enhancing alpha mannosidase like protein 2; ER degradation enhancing mannosidase like protein 2; ER degradation-enhancing alpha-mannosidase-like 2; FLJ10783; UNQ573/PRO1135
Target Background
In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).
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