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The antibody against ERI1 was raised in rabbit using the Recombinant Human 3\'-5\' exoribonuclease 1 protein (2-66AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against ERI1 was raised in rabbit using the Recombinant Human 3\’-5\’ exoribonuclease 1 protein (2-66AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
$299.00
| Cat.No | ADC-07275A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ERI1 |
| Form | Liquid | Species Reactivity | Human, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human 3\'-5\' exoribonuclease 1 protein (2-66AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IV48 |
Uniprot Id
Q8IV48
Target Species
Human
Target Name
ERI1
Target Full Name
3'-5' exoribonuclease 1
Target Function
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus.
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