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The antibody against FLII was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human FLII (NP_002009.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against FLII was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human FLII (NP_002009.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-00605A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FLII |
| Target Synonyms | FLI; FLIL; Fli1; FLII | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, 293T, A-549, Jurkat | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human FLII (NP_002009.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q13045 | Immunogen Sequence |
Uniprot Id
Q13045
Target Species
Human
Target Name
FLII
Target Full Name
Protein flightless-1 homolog
Target Function
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation.
Target Subcellular Location
Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, focal adhesion.
Target Tissue Specificity
Strongest expression in skeletal muscle with high expression also in the heart and lung.
Target Research Area
Cell Biology
Target Synonyms
Fli 1; FLI; Fli1; Flightless 1; Flightless I (Drosophila) homolog; Flightless I homolog; Flightless I homolog (Drosophila); Flightless1; FlightlessI; fliI; FLII_HUMAN; Fliih; FLIL; MGC39265; Protein flightless 1 homolog; Protein flightless-1 homolog
Target Background
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
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