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The antibody against GCAT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-419 of human GCAT (NP_055106.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against GCAT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 170-419 of human GCAT (NP_055106.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-04827A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GCAT |
| Target Synonyms | KBL; GCAT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse eye | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 170-419 of human GCAT (NP_055106.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O75600 | Immunogen Sequence |
Uniprot Id
O75600
Target Species
Human
Target Name
GCAT
Target Full Name
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Target Subcellular Location
Mitochondrion. Nucleus. Note=Translocates to the nucleus upon cold and osmotic stress.
Target Protein Families
Class-II pyridoxal-phosphate-dependent aminotransferase family
Target Tissue Specificity
Strongly expressed in heart, brain, liver and pancreas. Also found in lung.
Target Synonyms
2 amino 3 ketobutyrate CoA ligase ; 2 amino 3 ketobutyrate coenzyme A ligase, mitochondrial; 2-amino-3-ketobutyrate coenzyme A ligase; AKB ligase; Aminoacetone synthase; GCAT; Glycine acetyltransferase; glycine C acetyltransferase ; glycine C acetyltransferase (2 amino 3 ketobutyrate coenzyme A ligase); KBL_HUMAN; KLB; mitochondrial
Target Background
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.
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