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The antibody against GUSB was raised in rabbit using the Recombinant Human Beta-glucuronidase protein (382-651AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against GUSB was raised in rabbit using the Recombinant Human Beta-glucuronidase protein (382-651AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human colon cancer using GUSB Antibody at dilution of 1:1002
| Cat.No | ADC-40104A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GUSB |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Beta-glucuronidase protein (382-651AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P08236 |
Uniprot Id
P08236
Target Species
Human
Target Name
GUSB
Target Full Name
Beta-glucuronidase
Target Function
Plays an important role in the degradation of dermatan and keratan sulfates.
Target Involvement
Mucopolysaccharidosis 7 (MPS7)
Target Subcellular Location
Lysosome.
Target Protein Families
Glycosyl hydrolase 2 family
Target Synonyms
Ac2-223; asd; Beta G1; Beta glucuronidase; Beta-G1; Beta-glucuronidase; BG; BGLR; BGLR_HUMAN; FLJ39445; Glucuronidase beta; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; GUSB; Gut; MPS7
Target Background
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4, 6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.
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