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The antibody against HAAO was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HAAO was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03932A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HAAO |
| Target Synonyms | HAO; 3-HAO; VCRL1; h3HAO; HAAO | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse spleen, Rat liver | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human HAAO (NP_036337.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P46952 | Immunogen Sequence |
Uniprot Id
P46952
Target Species
Human
Target Name
HAAO
Target Full Name
3-hydroxyanthranilate 3,4-dioxygenase
Target Function
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
3-HAO family
Target Synonyms
3 HAO; 3 hydroxyanthranilate 3 4 dioxygenase; 3 hydroxyanthranilate dioxygenase; 3 hydroxyanthranilate oxygenase; 3 hydroxyanthranilic acid dioxygenase; 3-HAO; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; 3HAO_HUMAN; haao; HAD; HAO
Target Background
3-Hydroxyanthranilate 3, 4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
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