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The antibody against HDAC10 was raised in rabbit using the Synthesized peptide derived from Human HDAC10. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against HDAC10 was raised in rabbit using the Synthesized peptide derived from Human HDAC10. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC10 antibody.
Western blot analysis of extracts from COS7 cells, using HDAC10 antibody.2
Western blot analysis of extracts from JK cells (Lane 2) and cos-7 cells (Lane 3), using HDAC10 antiobdy. The lane on the left is treated with synthesized peptide.3
| Cat.No | ADC-42390A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HDAC10 |
| Target Synonyms | DKFZP761B039 antibody; HD 10 antibody; HD10 antibody; HDA10_HUMAN antibody; HDAC 10 antibody; Hdac10 antibody; Histone deacetylase 10 antibody; MGC149722 antibody; OTTHUMP00000028555 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from Human HDAC10. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q969S8 |
Uniprot Id
Q969S8
Target Species
Human
Target Name
HDAC10
Target Full Name
Polyamine deacetylase HDAC10
Target Function
Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Histone deacetylase family, HD type 2 subfamily
Target Tissue Specificity
Widely expressed with high levels in liver and kidney.
Target Synonyms
DKFZP761B039; HD 10; HD10; HDA10_HUMAN; HDAC 10; Hdac10; Histone deacetylase 10; MGC149722; OTTHUMP00000028555
Target Background
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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