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The antibody against HSD17B3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against HSD17B3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-00072A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | HSD17B3 |
| Target Synonyms | EDH17B3; SDR12C2; HSD17B3 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T transfected with HSD17B3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human HSD17B3 (NP_000188.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P37058 | Immunogen Sequence |
Uniprot Id
P37058
Target Species
Human
Target Name
HSD17B3
Target Full Name
17-beta-hydroxysteroid dehydrogenase type 3
Target Function
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms.
Target Involvement
Male pseudohermaphrodism with gynecomastia (MPH)
Target Subcellular Location
Endoplasmic reticulum.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
Target Tissue Specificity
Testis.
Target Synonyms
17 @beta HSD III; 17 beta HSD 3; 17-@beta hydroxysteroid dehydrogenase III; 17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; DHB3_HUMAN; EC 1.1.1.64; EDH17B3; Estradiol 17 beta dehydrogenase ; Estradiol 17 beta dehydrogenase 3; HSD17B3; Hydroxysteroid (17 beta) dehydrogenase 3; OTTHUMP00000021718; SDR12C2; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17 @beta hydroxysteroid dehydrogenase III; Testicular 17 beta hydroxysteroid dehydrogenase ; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17 beta dehydrogenase 3; Testosterone 17-beta-dehydrogenase 3
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