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Rabbit anti-Human IGFBP6 Polyclonal Antibody

The antibody against IGFBP6 was raised in rabbit using the Recombinant Human Insulin-like growth factor-binding protein 6 protein (32-161AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.

ADC-08531A

The antibody against IGFBP6 was raised in rabbit using the Recombinant Human Insulin-like growth factor-binding protein 6 protein (32-161AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.

$299.00

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Specifications


Cat.No ADC-08531A ClonalityPolyclonal
Host SpeciesRabbitTarget NameIGFBP6
FormLiquidSpecies ReactivityHuman
IsotypeIgGStorage Buffer0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4
Purification Method>95%, Protein G purifiedConjugateNon-conjugated
ApplicationELISA, IHCStorageUpon receipt

Immunogen Information


Immunogen DescriptionRecombinant Human Insulin-like growth factor-binding protein 6 protein (32-161AA)Target SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP24592
Background Information
  • Uniprot Id

    P24592

  • Target Species

    Human

  • Target Name

    IGFBP6

  • Target Full Name

    Insulin-like growth factor-binding protein 6

  • Target Function

    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.

  • Target Subcellular Location

    Secreted.

  • Target Synonyms

    IBP 6; IBP-6; IBP6; IBP6_HUMAN; IGF binding protein 6; IGF-binding protein 6; IGFBP 6; IGFBP-6; IGFBP6; Insulin like growth factor binding protein 6; Insulin-like growth factor-binding protein 6

  • Target Background

    Enables identical protein binding activity and insulin-like growth factor II binding activity. Involved in cell migration and positive regulation of stress-activated MAPK cascade. Part of insulin-like growth factor binary complex. Implicated in obesity. Biomarker of breast cancer; in situ carcinoma; leiomyoma; and neovascular inflammatory vitreoretinopathy.

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