Rabbit anti-Human ING1 Polyclonal Antibody

Uniprot Id

Q9UK53

Target Species

Human

Target Name

ING1

Target Full Name

Inhibitor of growth protein 1

Target Function

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Target Involvement

Squamous cell carcinoma of the head and neck (HNSCC)

Target Subcellular Location

Nucleus.

Target Protein Families

ING family

Target Tissue Specificity

Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and c

Target Synonyms

2610028J21Rik; AA407184; AI875420; Growth inhibitor ING 1; Growth inhibitor ING1; Growth inhibitory protein ING 1; Growth inhibitory protein ING1; Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds ; ING 1; Ing1; ING1_HUMAN; Inhibitor of growth 1; Inhibitor of growth family member 1; Inhibitor of growth protein 1; mING1h; OTTHUMP00000018703; OTTHUMP00000018704; OTTHUMP00000018705; OTTHUMP00000018706; p24ING1c; p33; p33 ING1; p33ING1; p33ING1b; p33ING1c; p37Ing1b; p47; p47ING1a; Tumor suppressor ING 1; Tumor suppressor ING1

Target Background

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.