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The antibody against IQCB1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Nephrocystin-5. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
The antibody against IQCB1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Nephrocystin-5. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on WB, IHC, ELISA.
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Western Blot analysis of SH-SY5Y cells using Nephrocystin-5 Polyclonal Antibody
Western Blot analysis of 293 Jurkat cells using Nephrocystin-5 Polyclonal Antibody2
| Cat.No | ADC-38117A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IQCB1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Nephrocystin-5. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q15051 |
Uniprot Id
Q15051
Target Species
Human
Target Name
IQCB1
Target Full Name
IQ calmodulin-binding motif-containing protein 1
Target Function
Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6.
Target Involvement
Senior-Loken syndrome 5 (SLSN5); Leber congenital amaurosis 10 (LCA10)
Target Subcellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localization to the centrosome depends on the interaction with CEP290/NPHP6.
Target Tissue Specificity
Ubiquitously expressed in fetal and adult tissues. Localized to the outer segments and connecting cilia of photoreceptor cells. Up-regulated in a number of primary colorectal and gastric tumors.
Target Synonyms
IQ calmodulin-binding motif containing 1; IQ calmodulin-binding motif-containing protein 1; IQ motif containing B1; Iqcb1; IQCB1_HUMAN; KIAA0036; Nephrocystin-5; NPHP5; p53 and DNA damage-regulated IQ motif protein; SLSN5
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