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The antibody against IZUMO1 was raised in rabbit using the Recombinant Human Izumo sperm-egg fusion protein 1 protein (22-292AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against IZUMO1 was raised in rabbit using the Recombinant Human Izumo sperm-egg fusion protein 1 protein (22-292AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human testis tissue using IZUMO1 Antibody at dilution of 1:100
Immunofluorescent analysis of A549 cells using IZUMO1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-19271A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IZUMO1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Izumo sperm-egg fusion protein 1 protein (22-292AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IYV9 |
Uniprot Id
Q8IYV9
Target Species
Human
Target Name
IZUMO1
Target Full Name
Izumo sperm-egg fusion protein 1
Target Function
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein.
Target Protein Families
Izumo family
Target Tissue Specificity
Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.
Target Research Area
Developmental Biology
Target Synonyms
FLJ61440; IZUM1_HUMAN; IZUMO; Izumo sperm egg fusion 1; Izumo sperm-egg fusion protein 1; Izumo1; MGC34799; OBF; Oocyte binding/fusion factor; Sperm specific protein izumo; Sperm-specific protein izumo
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