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The antibody against JPH2 was raised in rabbit using the Human Jph2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
The antibody against JPH2 was raised in rabbit using the Human Jph2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, IHC.
$600.00
| Cat.No | ADC-48203A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | JPH2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Human Jph2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BR39 |
Uniprot Id
Q9BR39
Target Species
Human
Target Name
JPH2
Target Full Name
Junctophilin-2
Target Function
Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release. Contributes to the construction of skeletal muscle triad junctions.; Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins.
Target Involvement
Cardiomyopathy, familial hypertrophic 17 (CMH17)
Target Subcellular Location
[Junctophilin-2]: Cell membrane; Peripheral membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein.; [Junctophilin-2 N-terminal fragment]: Nucleus.
Target Protein Families
Junctophilin family
Target Tissue Specificity
Specifically expressed in skeletal muscle and heart.
Target Synonyms
FLJ40969; JP-2; JP2; Jph2; JPH2_HUMAN; Junctophilin 2; Junctophilin type 2; Junctophilin-2; OTTHUMP00000031651; OTTHUMP00000031652
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