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The antibody against KLB was raised in rabbit using the Recombinant Human Beta-klotho protein (1-130AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against KLB was raised in rabbit using the Recombinant Human Beta-klotho protein (1-130AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
| Cat.No | ADC-03980A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KLB |
| Target Synonyms | Beta-klotho antibody; BetaKlotho antibody; BKL antibody; KLB antibody; KLOTB_HUMAN antibody; Klotho beta like protein antibody; Klotho beta-like protein antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Beta-klotho protein (1-130AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86Z14 |
Uniprot Id
Q86Z14
Target Species
Human
Target Name
KLB
Target Full Name
Beta-klotho
Target Function
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
Target Subcellular Location
Cell membrane; Single-pass type III membrane protein.
Target Protein Families
Glycosyl hydrolase 1 family, Klotho subfamily
Target Synonyms
Beta-klotho; BetaKlotho; BKL; KLB; KLOTB_HUMAN; Klotho beta like protein; Klotho beta-like protein
Target Background
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be active in endoplasmic reticulum.
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