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The antibody against KLHL3 was raised in rabbit using the Synthesized peptide derived from N-terminal of Human KLHL3. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against KLHL3 was raised in rabbit using the Synthesized peptide derived from N-terminal of Human KLHL3. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC, IF.
$297.00
Western blot analysis of extracts from RAW264.7 cells and 3T3 cells, using KLHL3 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KLHL3 antibody.2
Immunofluorescence analysis of A549 cells, using KLHL3 antibody.3
| Cat.No | ADC-41769A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | KLHL3 |
| Target Synonyms | KLHL3 antibody; KIAA1129 antibody; Kelch-like protein 3 antibody | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from N-terminal of Human KLHL3. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UH77 |
Uniprot Id
Q9UH77
Target Species
Human
Target Name
KLHL3
Target Full Name
Kelch-like protein 3
Target Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation. The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney.
Target Involvement
Pseudohypoaldosteronism 2D (PHA2D)
Target Subcellular Location
Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
Target Tissue Specificity
Widely expressed.
Target Synonyms
KLHL3; KIAA1129; Kelch-like protein 3
Target Background
This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D); a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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