Rabbit anti-Human LAMA3 Polyclonal Antibody

Uniprot Id

Q16787

Target Species

Human

Target Name

LAMA3

Target Full Name

Laminin subunit alpha-3

Target Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.; Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.

Target Involvement

Epidermolysis bullosa, junctional, Herlitz type (H-JEB); Laryngoonychocutaneous syndrome (LOCS)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Target Tissue Specificity

Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expres

Target Synonyms

E170; Epiligrin 170 kDa subunit; Epiligrin subunit alpha; Kalinin B1 chain; Kalinin subunit alpha; LAMA3; LAMA3_HUMAN; LAMB3; LAMC2; Laminin gamma 2; Laminin 5 beta 3; Laminin 5 gamma 2 subunit; Laminin beta 3; Laminin subunit alpha-3; Laminin subunit beta 3; Laminin subunit gamma 2; Laminin-5 subunit alpha; Laminin-6 subunit alpha; Laminin-7 subunit alpha; Nicein subunit alpha