Rabbit anti-Human LIME1 Polyclonal Antibody

Uniprot Id

Q9H400

Target Species

Human

Target Name

LIME1

Target Full Name

Lck-interacting transmembrane adapter 1

Target Function

Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.

Target Subcellular Location

Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.

Target Tissue Specificity

Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).

Target Synonyms

LIME1; LIME; LP8067; Lck-interacting transmembrane adapter 1; Lck-interacting membrane protein; Lck-interacting molecule

Target Background

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants.