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The antibody against M6PR was raised in rabbit using the Recombinant Human Cation-dependent mannose-6-phosphate receptor protein (1-277AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against M6PR was raised in rabbit using the Recombinant Human Cation-dependent mannose-6-phosphate receptor protein (1-277AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
$299.00
Immunohistochemistry of paraffin-embedded human testis tissue using M6PR Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using M6PR Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using M6PR Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-46133A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | M6PR |
| Target Synonyms | M6PR; MPR46; MPRD; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Cation-dependent mannose-6-phosphate receptor protein (1-277AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P20645 |
Uniprot Id
P20645
Target Species
Human
Target Name
M6PR
Target Full Name
Cation-dependent mannose-6-phosphate receptor
Target Function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Target Subcellular Location
Lysosome membrane; Single-pass type I membrane protein.
Target Synonyms
M6PR; MPR46; MPRD; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46
Target Background
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
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