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The antibody against MACROD1 was raised in rabbit using the Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MACROD1 was raised in rabbit using the Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using MACROD1 Antibody at dilution of 1:100
| Cat.No | ADC-22632A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MACROD1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BQ69 |
Uniprot Id
Q9BQ69
Target Species
Human
Target Name
MACROD1
Target Full Name
ADP-ribose glycohydrolase MACROD1
Target Function
Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity.
Target Involvement
A chromosomal aberration involving MACROD1 is found in acute leukemia. Translocation t(11;21)(q13;q22) that forms a RUNX1-MACROD1 fusion protein.
Target Subcellular Location
Nucleus.
Target Research Area
Cancer
Target Synonyms
MACROD1; LRP16; ADP-ribose glycohydrolase MACROD1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; EC 3.1.1.106; Protein LRP16; [Protein ADP-ribosylaspartate] hydrolase MACROD1; EC 3.2.2.-; [Protein ADP-ribosylglutamate] hydrolase MACROD1; EC 3.2.2.-
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