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The antibody against MAGEF1 was raised in rabbit using the Synthetic peptide of Human MAGEF1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against MAGEF1 was raised in rabbit using the Synthetic peptide of Human MAGEF1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-26400A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MAGEF1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human MAGEF1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HAY2 |
Uniprot Id
Q9HAY2
Target Species
Human
Target Name
MAGEF1
Target Full Name
Melanoma-associated antigen F1
Target Function
Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
MAGE F1 antigen; MAGE-F1 antigen; MAGEF 1; MAGEF1; MAGF1_HUMAN; Melanoma antigen family F; 1; Melanoma associated antigen F1; Melanoma-associated antigen F1; MGC19617
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