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The antibody against MTTP was raised in rabbit using the Recombinant Human Microsomal triglyceride transfer protein large subunit protein (19-151AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against MTTP was raised in rabbit using the Recombinant Human Microsomal triglyceride transfer protein large subunit protein (19-151AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human small intestine tissue using MTTP Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human liver cancer using MTTP Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using MTTP Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-14645A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MTTP |
| Target Synonyms | mitochondrial, mitochondrial antibody, proline antibody; tRNA-Pro | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Microsomal triglyceride transfer protein large subunit protein (19-151AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P55157 |
Uniprot Id
P55157
Target Species
Human
Target Name
MTTP
Target Full Name
Microsomal triglyceride transfer protein large subunit
Target Function
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins.
Target Involvement
Abetalipoproteinemia (ABL)
Target Subcellular Location
Endoplasmic reticulum. Golgi apparatus.
Target Tissue Specificity
Liver and small intestine. Also found in ovary, testis and kidney.
Target Synonyms
ABL; Microsomal triglyceride transfer protein (large polypeptide 88kDa); Microsomal triglyceride transfer protein 88kD; Microsomal triglyceride transfer protein; Microsomal triglyceride transfer protein large subunit; MTP; MTP large subunit; MTP_HUMAN; MTTP; Transfer RNA, mitochondrial, proline; tRNA-Pro, mitochondrial
Target Background
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
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