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The antibody against NANOS2 was raised in rabbit using the Recombinant Human Nanos homolog 2 protein (1-138AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against NANOS2 was raised in rabbit using the Recombinant Human Nanos homolog 2 protein (1-138AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human ovarian cancer using NANOS2 Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using NANOS2 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-21813A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NANOS2 |
| Target Synonyms | NANO2_HUMAN antibody; Nanos homolog 2 antibody; Nanos homolog 2 Drosophila antibody; NANOS2 antibody; NOS-2 antibody; NOS2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Nanos homolog 2 protein (1-138AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P60321 |
Uniprot Id
P60321
Target Species
Human
Target Name
NANOS2
Target Full Name
Nanos homolog 2
Target Function
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.
Target Subcellular Location
Cytoplasm. Cytoplasm, P-body. Cytoplasm, perinuclear region.
Target Protein Families
Nanos family
Target Tissue Specificity
Testis and ovary. Expression found in several spermatogenic stages: in cells on the periphery of the tubules which could correspond to spermatogonia, in spermatocytes and in round spermatids (at protein level).
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
NANO2_HUMAN; Nanos homolog 2; Nanos homolog 2 Drosophila; NANOS2; NOS-2; NOS2
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