Rabbit anti-Human NCL Polyclonal Antibody

The antibody against NCL was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 300-466 of human NCL (NP_005372.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-12328A

Number

Cat.No	ADA-12328A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	NCL
Target Synonyms	C23; Nsr1; NCL	Form	Liquid
Species Reactivity	Human, Mouse	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	A-549, MCF7, THP-1	Application	ELISA, WB, IHC-P

Cat.No

ADA-12328A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

NCL

Target Synonyms

C23; Nsr1; NCL

Form

Liquid

Species Reactivity

Human, Mouse

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

A-549, MCF7, THP-1

Application

ELISA, WB, IHC-P

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 300-466 of human NCL (NP_005372.2).	Target Species	Human
Immunogen Sequence	GTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGE	Uniprot ID	P19338

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 300-466 of human NCL (NP_005372.2).

Target Species

Human

Immunogen Sequence

GTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGE

Uniprot ID

P19338

Background Information

Uniprot Id

P19338
Target Species

Human
Target Name

NCL
Target Full Name

Nucleolin
Target Function

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
Target Subcellular Location

Nucleus, nucleolus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

C23; FLJ45706; MS1116 ; NCL; Nucl; NUCL_HUMAN; Nucleolin; Protein C23
Target Background

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.

Rabbit anti-Human NCL Polyclonal Antibody

Specifications

Immunogen Information

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