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The antibody against PDE4A was raised in rabbit using the Synthetic peptide of Human PDE4A as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against PDE4A was raised in rabbit using the Synthetic peptide of Human PDE4A as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-26187A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | PDE4A |
| Target Synonyms | 5''-cyclic phosphodiesterase 4A antibody; cAMP specific phosphodiesterase antibody; cAMP-specific 3'' antibody; cAMP-specific 3', cAMP-specific (dunce antibody; phosphodiesterase E2 dunce homolog antibody; Phosphodiesterase E2 dunce homolog, Drosophila antibody; phosphodiesterase isozyme 4 antibody; phosphodiesterase type 4A11 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.05% NaN3, 40% Glycerol., pH7.4 PBS | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide of Human PDE4A | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P27815 |
Uniprot Id
P27815
Target Species
Human
Target Name
PDE4A
Target Full Name
3',5'-cyclic-AMP phosphodiesterase 4A
Target Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Target Subcellular Location
[Isoform 1]: Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.; [Isoform 4]: Membrane; Peripheral membrane protein. Note=Isoform 4 has propensity for association with membranes.; [Isoform 6]: Cytoplasm, perinuclear region.; [Isoform 7]: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.
Target Protein Families
Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
Target Tissue Specificity
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Iso
Target Synonyms
PDE4; DPDE2; PDE46; PDE4A
Target Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
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